From Sydney:
3.5 hour drive (261 km). Take the Great Western Highway through the Blue Mountains or alternatively the Bells Line of Road through Windsor. Turn off for Mudgee just past Lithgow.

From Newcastle:
3.5 hour drive (290 km). Take New England Highway to Singleton. Turn off for Jerry's Plains, through Denman, Sandy Hollow, Merriwa. Turn off for Mudgee just past the Cassilis intersection.

From Canberra:
6 hour drive (471km). Through Yass to Boorowa, Cowra, Canowindra, Molong, Wellingtonto Mudgee. Alternatively Cowra to Bathurst, Sofala, Ilford and Mudgee.

From Brisbane:
11 hour drive. Follow the Newell Highway to Dubbo then head East for Mudgee or alternatively the New England Highway to Tamworth, then through Gunnedah, Tambar Springs to Coolah and Mudgee.